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Assist. Prof. Mehmet Ozansoy, Ph.D.

I am a molecular biologist working in the field of neuroscience. My main focus is to elucidate the molecular/cellular mechanisms underlying neurodegenerative disorders, especially Alzheimer's Disease, I am currently working on the mechanistic relationships between systemic inflammation and neurodegeneration in various in vitro models.


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International Publications in Peer-Reviewed Journals

Ozansoy M, Mikati H, Velioglu VA, Yulug B, “Exosomes: A missing link between chronic systemic inflammation and Alzheimer's disease?”, Biomed Pharmacother  2023 Jan 13;159:114161. doi: 10.1016/j.biopha.2022.114161.

Sahin Z, Biltekin SN, Ozansoy M, Hemiş B, Ozansoy MB, Yurttaş L, Berk B, Demirayak Ş, “Synthesis and in vitro antitumor activities of novel thioamide substituted piperazinyl‐1, 2, 4‐triazines”, Journal of Heterocyclic Chemistry, 2022, 59: 1333-1340. doi: 10.1002/jhet.4470

Ilktac HY, Kiziltan G, Lanpir AD, Ozansoy M, Gunal MY, Ozmen ST, Keskin I, Ozdemir EM, Kilic U, “Combined therapy with probiotic VSL# 3 and Omega-3 fatty acids attenuates colonic injury and inflammation in chronic DNBS-induced colitis in mice”, Folia Biologica (Krakow), 2021, 69(3), pp:135-146. doi: 10.3409/fb_69-3.15

Ilktac HY, Kiziltan G, Ozansoy M, Kilic U, Ozmen ST, Keskin I, Ozdemir EM, Gunal MY, “The effect of probiotic and omega-3 supplements on total oxidant and total antioxidant levels in experimental colitis”, Clinical and Experimental Health Sciences, 2021, 11(2), pp: 362-366.                                 doi: 10.33808/clinexphealthsci.865058.

Avnioglu S, Ozansoy M, Cankaya S, Yildiz K, Hanoglu T, Polat B, Hanoglu L, “Empathy and Telepathy-Functional Imaging Psychiatric and Philosophic Correlates”, Biomedical Journal of Scientific & Technical Research, 2021, 38(5), pp: 30718-30720. doi: 10.26717/BJSTR.2021.38.006209 

Ozansoy M, Altıntaş MÖ, Ozansoy MB, Günay N, Kılıç E, Kılıç Ü, “Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model”, Turkish Journal of Biology, 2020, doi: 10.3906/biy-2001-22

Ozansoy M, Ozansoy MB, Yulug B, Cankaya S, Kilic E, Goktekin S, Kilic U, “Melatonin Affects the Release of Exosomes and Tau-Content in In Vitro Amyloid-Beta Toxicity Model”, J Clin Neurosci, 2020, 73: 237-244, doi: 10.1016/j.jocn.2019.11.046

Yulug B, Saatci O, Isiklar A, Kilic U, Hanoglu L, Ozansoy M, Cankaya S, Cankaya B, Kilic E, “The association between HbA1c levels, olfactory memory and cognition in normal, pre-diabetic and diabetic persons” Endocr Metab Immune Disord Drug Targets. 2020 20(2): 198-212, doi: 10.2174/1871530319666190614121738

Günal MY, Yuluğ B, Çağlayan B, Ozansoy M, Kilic U, Keskin I, Kilic E, “A different view on the platelet aggregation inhibitor clopidogrel-a well-suitable anti-oedema agent in a preclinical model of brain injury”, Cesk Slov Neurol N 2019, 82: 115/5, 526-532. doi: 10.14735/amcsnn2019526

Şakul AA, Ozansoy M, Elibol B, Ayla Ş, Günal MY, Yozgat Y, Başağa SH, Şahin K, Kazancıoğlu R, Kılıç Ü, “Squalene Activates AKT/mTOR Pathway Against Cisplatin-Induced Kidney Damage”, Turkish Journal of Biology 2019 43: 179-188. doi:10.3906/biy-1902-77. Equally contributed author

Yulug B, Ozansoy M, Cankaya S, Hanoglu L, Kilic U, Kilic E, “A Different View on the Pathophysiology of Parkinson’s Disease: A Descendent Neurochemical Hypothesis?” Neural Regen Res. 2019 Oct; 14(10): 1717-1718. doi: 10.4103/1673-5374.257527. Equally contributed author

Yuluğ B, Ozansoy M, Alökten M, Çetin-Ozansoy MB, Çankaya Ş, Hanoğlu L, Kılıç Ü, Kılıç E. “Minocycline increases in vitro cortical neuronal cell survival after laser axotomy”. Curr Clin Pharmacol. Feb 25, 2019. doi: 10.2174/1574884714666190226093119 Equally contributed author


Ceylan B, Ozansoy M, Kılıç Ü, Yozgat Y, Ercan Ç, Yıldız P, Aslan T, “N-acetylcysteine suppresses colistimethate sodium-induced nephrotoxicity via activation of SOD2, eNOS, and MMP3 protein expressions”, Renal Failure, Vol:40(1), pp:423-434, 2018. 

Mazi AR, Arzuman AS, Gurel B, Sahin B, Tuzuner MB, Ozansoy M, Baykal AT, “Neonatal Neurodegeneration in Alzheimer’s Disease Transgenic Mouse Model”, Journal of Alzheimer’s Disease Reports, Vol:2(1), pp: 79-91, 2018.

Gurel B, Cansev M, Sevinc C, Kelestemur S, Ocalan B, Cakir A, Aydin S, Kahveci N, Ozansoy M, Taskapilioglu O, Ulus IH, Başar MK, Sahin B, Tuzuner MB, Baykal AT, “Early Stage Alterations in CA1 Extracellular Region Proteins Indicate Dysregulation of IL6 and Iron Homeostasis in the 5XFAD Alzheimer’s Disease Mouse Model”, J. Alzheimers Dis., Vol: 61(4), pp:1399-1410, 2018.

Yulug B, Hanoglu L, Ozansoy M, Isik D, Kilic U, Kilic E, Schabitz WR, “The Therapeutic Role of Rifampicin in Alzheimer’s Disease”, Psychiatry Clin. Neurosci. Jan. 8, 2018.

Keskin I, Günal MY, Aytürk N, Kilic U, Ozansoy M, Kilic E, "Dose-dependent Neuroprotective Effect of Enoxaparin on Cold-Induced Traumatic Brain Injury", Neural Regen Res, 12(5), pp: 761-764, 2017.

V Karatay, Y Denizhan, M Ozansoy, “Semiosis as Individuation: Integration of Multiple Orders of Magnitude”, Biosemiotics, October, pp:1-17, 2016.

AH Yamac, S Kucukbuzcu, M Ozansoy, O Gok, K Oz, M Erturk, E Yilmaz, B Ersoy, R Zeybek, O Goktekin, U Kilic, “Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery”, Cardiovascular Pathology, 25(3): 232-236, 2016.

M. Ozansoy, A.N. Başak, “The Central Theme of Parkinson’s Disease: α-Synuclein”, Molecular Neurobiology, 47(2): 460-465, 2013.

G. Cobanoglu, M. Ozansoy, A. N. Başak, “Are Alsin and Spartin Novel Interaction Partners?”, Biochemical and Biophysical Research Communications (BBRC), 427(1): 1-4, 2012.

I. Enunlu, M. Ozansoy, A. N. Başak, “Alfa-Class Prefoldin Protein UXT is a novel Interacting Partner of  Amyotrophic Lateral Sclerosis 2 (Als2) Protein”, Biochemical and Biophysical Research Communications (BBRC), 413(3); pp:471-475, September 30, 2011.

M. Ozansoy, Y. Denizhan, “The Endomembrane System: A Representation of the Extracellular Medium?”, Biosemiotics, Vol. 2, No: 3, pp: 255-267, 2009.

H.A. Hanagasi , P. Serdaroglu , M. Ozansoy , N. Basak , H. Tasli , M. Emre , “Mitochondrial Pathology in Muscle of a Patient with a Novel Parkin Mutation”, International Journal of Neuroscience, Vol. 119, No:10, pp: 1572-1583, 2009. 

M. Ozansoy, A. N. Başak, “Tauopathies: A Distinct Class of Neurodegenerative Diseases”, Balkan Journal of Medical Genetics, Vol. 10 No: 2, pp: 3-14, 2007.

M. Ozansoy, A.N. Başak, “Is Cell Death in Parkinson’s Disease Really Apoptosis?”, Balkan Journal of Medical Genetics,Vol. 9, No:1&2, pp:3-7, 2006.

HR Morris, R Katzenschlager, JC Janssen, JM Brown, M Ozansoy, N Quinn, T Revesz, MN Rossor, SE Daniel, NW Wood, AJ Lees. “Sequence Analysis of Tau in Familial and Sporadic Progressive Supranuclear Palsy”, Journal of Neurology, Neurosurgery and Psychiatry, 72:  388-390, 2002.


HR Morris MRCP, NL Khan BSc, JC Janssen MRCP, J Brown MD, J Perez-Tur PhD, M Baker BSc, M Ozansoy MSc, J Hardy PhD, M Hutton PhD, NW Wood PhD, AJ Lees MD, T Revesz MD, P Lantos MD, MN Rossor MD. “The Genetic and Pathological Classification of Familial Frontotemporal Dementia”, Archives of Neurology, Vol: 58, pp: 1813-1816 Nov 2001.


National Publications in Peer-Reviewed Journals

M Ozansoy, E Coşkun, MBÇ Ozansoy, Ş Çankaya, MY Günal, Z Bayraktaroğlu, B Yuluğ, L Hanoğlu, “The effect of rifampicin on the neuronal cell survival in primary cortical neuron culture after laser axotomy”, Acta Medica Alanya, 2019; 3(2): 135-140. doi: 10.30565/medalanya.553846

M Ozansoy, MB Çetin Ozansoy, “Changes in Als2 Expression Leads to Different Outcomes on the Expression of Two NF-kB Targeted Genes in N2a and C2C12 Cell Lines”, Med Med J 2019; 34: 123-129. doi:10.5222/MMJ.2019.05945.

Günal MY, Ozansoy M, Kılıç Ü, Keskin İ, Özdemir EM, Aslan İ, Eren Z, Ersavaş C, Kılıç E, “Role of erythropoietin and its receptor in the development of endometriosis in rats”, J  Turk Ger Gynecol Assoc, 20(1); pp:41-46, 2019.

MB Cetin Ozansoy, M Ozansoy, “Als2 Silencing Affects the Expression of Two NF-κB Targeted Genes via UXT in Adult Mouse Primary Spinal Motor Neuron Culture”, Med Med J, Vol:33, No:3, pp:227-234, 2018.

M. Ozansoy, A. N. Başak, “Tauopathies: A Distinct Class of Neurodegenerative Diseases”, Turkish Journal of Neurology (Turkish), Vol. 13, No: 1, pp: 1-29, 2007.

M. Ozansoy, A.N. Başak, “Programmed Cell Death in Parkinson’s Disease”, Journal of Parkinson’s Disease and Movement Disorders (Turkish), Vol: 9, No: 1, pp: 54-61, 2006.


Conference Presentations Published in Conference Books

Artun Kanıt, Bervis Hemiş, Nilsu Yurtseven, Zeynep Aslı Durak, Mehmet Ozansoy, "Boron Affects the Viability and Oxidative Stress in Burkitt Lymphoma Cell Line RAJI", pp: 53-60, 3rd International Congress on Innovative Approaches in Medical and Health Sciences, October 7-8 2023 (Published in full text)

Nilsu Yurtseven, Bervis Hemiş, Artun Kanıt, Zeynep Aslı Durak, Mehmet Ozansoy, “Investigation of Possible Anti-Cancer Effects of Boron Derivatives on C6 Rat Glioma Cell Line”, pp:198, 1st International Medicine and Pharmacy Congress, September 16 2023.

Bervis Hemiş, Elif Bilge Şimşek, Mehmet Ozansoy, “Investigation of Anti-Tumor Effect of Plantago Asiatica Plant Extract on C6 Glioma Cell Line”, pp: 423, 4th International Congress on Medical Sciences and Multidisciplinary Approaches, March 26-27-28 2022. (Published in full text)

Mehmet Ozansoy, Yağmur Denizhan, A. Nazlı Başak, “Effects of extremely low frequency electromagnetic fields on caspase activities”, pp: 345-351, 1st International Congress on Medical Sciences and Multidisciplinary Approaches, February 20-21, 2021. (Published in full text)

Mehmet Ozansoy, Mehmet Özgen Altıntaş, Muzaffer Beyza Ozansoy, “Sodium borate decahydrate affects the fractal dimension of SH-SY5Y cells in an in vitro amyloid-beta toxicity model” pp: 86, International Eurasian Conference on Biotechnology and Biochemistry, December 16-18, 2020.

Muzaffer Beyza Ozansoy, Mehmet Ozansoy, “The Effect of N,N-dimethyltryptamine on the fractal dimension of neurite outbranching”, pp:77, 18th Turkish Neuroscience Congress, November 6-9, 2020.

Mehmet Ozansoy, Cennet Sena Parlatan, Beyza Çetin Ozansoy, Lütfü Hanoğlu, “Investigation of the effects of two boron containing compounds on neuronal survival in an in vitro axotomy model”, pp:370, 2nd International Eurasian Conference on Biological and Chemical Sciences, June 28-29, 2019.


Mehmet Ozansoy, “Effects of extremely low frequency electromagnetic fields on caspase activities”, pp:209, International Eurasian Conference on Science, Engineering and Technology, November 22-23, 2018. 

Mehmet Ozansoy, M. Özgen Altıntaş, Ülkan Kılıç, “Effects of two boron containing compounds and melatonin in Aβ1-42 toxicity”, pp:17; OC-007, 3rd International Congress of Turkish Neuroendocrinology Society, 29th June-1st July 2018.

Muzaffer Beyza Ozansoy, Mehmet Ozansoy, Nuran Darıyerli, “The Role of Sigma-1 Receptor on Neurite Outgrowth in Primary Hippocampal Neurons” 16th National Neuroscience Congress, pp:98, May 20-23 2018.

Yoldas H, Kiziltan G, Togay SÖ, Keskin I, Ozansoy M, Kilic U, Yiğit P, Özdemir EM, Günal MY, “Effects of Probiotics and Omega-3 Fatty Acids on Inflammatory Response in Experimental Colitis Model” 17th International Nutrition & Diagnostics Conference, pp:13, October 9-12 2017.

Mehmet Ozansoy, Neşe Ayşit Altuncu, Fatma İlayda Aydınlı, Esra Nur Ekmekçioğlu, Gürkan Öztürk, “The Therapeutic Application of Cell Suspension Isolated from Axolotl to Mouse Spinal Cord Injury” 15th National Neuroscience Congress, pp:46, May 07-10 2017.

Mehmet Ozansoy, Muzaffer Beyza Çetin Ozansoy, Fikrettin Şahin, Ülkan Kılıç, “The Effect of Melatonin on the Exosome Release and Exosomal Content in In Vitro Amyloid-Beta Toxicity Model” 42nd National Physiology Congress, pp:42, September 05-08 2016.

MY. Günal, M. Ozansoy, İ. Keskin, Z. Eren, İ. Aslan, E. Kılıç, “ Comparative Effects of Erythropoietin-β, Darbepoietin-α and MIRCERA on Endometriotic Foci in Homologous Rat Endometriosis Model”, 40th National Physiology Congress, Abstract Book:105, Kayseri, 2014. 

M. Ozansoy, “Recent Advances in Neuroscience-Optogenetic Approaches”, 11th National Neuroscience Congress, Ege University, School of Medicine, İzmir, Turkey, 28 April-1 May, 2013.

Y. Denizhan, M. Ozansoy, V. Karatay, “Information in Biological Individuation”, 12th Gatherings in Biosemiotics, Tartu, Estonia, July 17-22, 2012.

M. Ozansoy, Y. Denizhan, “Endomembrane System: A Representation of the Extracellular Medium”, 8th Gatherings in Biosemiotics, Syros, Greece, 2008.

M. Ozansoy, Y. Denizhan, “Disease as Semiotic Misinterpretation, a Model Study: Parkinson’s Disease,”, 4th Gatherings in Biosemiotics, Prague, Czhec Republic, 2004.

H.A. Hanağası, M. Ozansoy, H.A. Şahin, B.Bilgiç, İ.H. Gürvit, J.Yazıcı, A. Brice, M. Emre, A.N. Başak, “Autosomal Recessive Juvenile Parkinsonism: A New Parkin Mutation and Clinical Heterogeneity between Family Members”, 39th National Neurology Congress,  2003.

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