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Neurodegeneration & Neurodegenerative Diseases

Research Articles & Reviews

Yulug B, Uygur B, Sayman D, Akturk A, Cankaya S, Ayyıldız B,  Ayyıldız S, Salar AB, Ozansoy M, Hanoglu L, Altay O, Velioglu HA , Mardinoglu A, “The Role of Willpower in Major Depressive Disorder: An fMRI Study”, SSRN, Preprints with the Lancet, doi: 10.2139/ssrn.4445188.

 

Ozansoy M, Mikati H, Velioglu VA, Yulug B, “Exosomes: A missing link between chronic systemic inflammation and Alzheimer's disease?”, Biomed Pharmacother  2023 Jan 13;159:114161. doi: 10.1016/j.biopha.2022.114161. Review

 

Avnioglu S, Ozansoy M, Cankaya S, Yildiz K, Hanoglu T, Polat B, Hanoglu L, “Empathy and Telepathy-Functional Imaging Psychiatric and Philosophic Correlates”, Biomedical Journal of Scientific & Technical Research, 2021, 38(5), pp: 30718-30720. doi: 10.26717/BJSTR.2021.38.006209

 

Ozansoy M, Altıntaş MÖ, Ozansoy MB, Günay N, Kılıç E, Kılıç Ü, “Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model”, Turkish Journal of Biology, 2020, doi: 10.3906/biy-2001-22

 

Ozansoy M, Ozansoy MB, Yulug B, Cankaya S, Kilic E, Goktekin S, Kilic U, “Melatonin Affects the Release of Exosomes and Tau-Content in In Vitro Amyloid-Beta Toxicity Model”, J Clin Neurosci, 2020, 73: 237-244, doi: 10.1016/j.jocn.2019.11.046

 

Yulug B, Saatci O, Isiklar A, Kilic U, Hanoglu L, Ozansoy M, Cankaya S, Cankaya B, Kilic E, “The association between HbA1c levels, olfactory memory and cognition in normal, pre-diabetic and diabetic persons” Endocr Metab Immune Disord Drug Targets. 2020 20(2): 198-212, doi: 10.2174/1871530319666190614121738

 

Günal MY, Yuluğ B, Çağlayan B, Ozansoy M, Kilic U, Keskin I, Kilic E, “A different view on the platelet aggregation inhibitor clopidogrel-a well-suitable anti-oedema agent in a preclinical model of brain injury”, Cesk Slov Neurol N 2019, 82: 115/5, 526-532. doi: 10.14735/amcsnn2019526

Yulug B, Ozansoy M, Cankaya S, Hanoglu L, Kilic U, Kilic E, “A Different View on the Pathophysiology of Parkinson’s Disease: A Descendent Neurochemical Hypothesis?” Neural Regen Res. 2019 Oct; 14(10): 1717-1718. doi: 10.4103/1673-5374.257527. Equally contributed author

 

Yuluğ B, Ozansoy M, Alökten M, Çetin-Ozansoy MB, Çankaya Ş, Hanoğlu L, Kılıç Ü, Kılıç E. “Minocycline increases in vitro cortical neuronal cell survival after laser axotomy”. Curr Clin Pharmacol. Feb 25, 2019. doi: 10.2174/1574884714666190226093119 Equally contributed author

Mazi AR, Arzuman AS, Gurel B, Sahin B, Tuzuner MB, Ozansoy M, Baykal AT, “Neonatal Neurodegeneration in Alzheimer’s Disease Transgenic Mouse Model”, Journal of Alzheimer’s Disease Reports, Vol:2(1), pp: 79-91, 2018.

 

Gurel B, Cansev M, Sevinc C, Kelestemur S, Ocalan B, Cakir A, Aydin S, Kahveci N, Ozansoy M, Taskapilioglu O, Ulus IH, Başar MK, Sahin B, Tuzuner MB, Baykal AT, “Early Stage Alterations in CA1 Extracellular Region Proteins Indicate Dysregulation of IL6 and Iron Homeostasis in the 5XFAD Alzheimer’s Disease Mouse Model”, J. Alzheimers Dis., Vol: 61(4), pp:1399-1410, 2018.

 

Yulug B, Hanoglu L, Ozansoy M, Isik D, Kilic U, Kilic E, Schabitz WR, “The Therapeutic Role of Rifampicin in Alzheimer’s Disease”, Psychiatry Clin. Neurosci. Jan. 8, 2018. Review.

G. Cobanoglu, M. Ozansoy, A. N. Başak, “Are Alsin and Spartin Novel Interaction Partners?”, Biochemical and Biophysical Research Communications (BBRC), 427(1): 1-4, 2012.

 

Keskin I, Günal MY, Aytürk N, Kilic U, Ozansoy M, Kilic E, "Dose-dependent Neuroprotective Effect of Enoxaparin on Cold-Induced Traumatic Brain Injury", Neural Regen Res, 12(5), pp: 761-764, 2017.

M. Ozansoy, A.N. Başak, “The Central Theme of Parkinson’s Disease: α-Synuclein”, Molecular Neurobiology, 47(2): 460-465, 2013. Review

I. Enunlu, M. Ozansoy, A. N. Başak, “Alfa-Class Prefoldin Protein UXT is a novel Interacting Partner of  Amyotrophic Lateral Sclerosis 2 (Als2) Protein”, Biochemical and Biophysical Research Communications (BBRC), 413(3); pp:471-475, September 30, 2011.

H.A. Hanagasi‌, P. Serdaroglu‌, M. Ozansoy‌, N. Basak‌, H. Tasli‌, M. Emre‌, “Mitochondrial Pathology in Muscle of a Patient with a Novel Parkin Mutation”, International Journal of Neuroscience, Vol. 119, No:10, pp: 1572-1583, 2009. 

 

M. Ozansoy, A. N. Başak, “Tauopathies: A Distinct Class of Neurodegenerative Diseases”, Balkan Journal of Medical Genetics, Vol. 10 No: 2, pp: 3-14, 2007. Review

 

M. Ozansoy, A.N. Başak, “Is Cell Death in Parkinson’s Disease Really Apoptosis?”, Balkan Journal of Medical Genetics,Vol. 9, No:1&2, pp:3-7, 2006. Review

 

HR Morris, R Katzenschlager, JC Janssen, JM Brown, M Ozansoy, N Quinn, T Revesz, MN Rossor, SE Daniel, NW Wood, AJ Lees. “Sequence Analysis of Tau in Familial and Sporadic Progressive Supranuclear Palsy”, Journal of Neurology, Neurosurgery and Psychiatry, 72:  388-390, 2002.

 

HR Morris MRCP, NL Khan BSc, JC Janssen MRCP, J Brown MD, J Perez-Tur PhD, M Baker BSc, M Ozansoy MSc, J Hardy PhD, M Hutton PhD, NW Wood PhD, AJ Lees MD, T Revesz MD, P Lantos MD, MN Rossor MD. “The Genetic and Pathological Classification of Familial Frontotemporal Dementia”, Archives of Neurology, Vol: 58, pp: 1813-1816 Nov 2001.

M Ozansoy, E Coşkun, MBÇ Ozansoy, Ş Çankaya, MY Günal, Z Bayraktaroğlu, B Yuluğ, L Hanoğlu, “The effect of rifampicin on the neuronal cell survival in primary cortical neuron culture after laser axotomy”, Acta Medica Alanya, 2019; 3(2): 135-140. doi: 10.30565/medalanya.553846

 

M Ozansoy, MB Çetin Ozansoy, “Changes in Als2 Expression Leads to Different Outcomes on the Expression of Two NF-kB Targeted Genes in N2a and C2C12 Cell Lines”, Med Med J 2019; 34: 123-129. doi:10.5222/MMJ.2019.05945.

MB Cetin Ozansoy, M Ozansoy, “Als2 Silencing Affects the Expression of Two NF-κB Targeted Genes via UXT in Adult Mouse Primary Spinal Motor Neuron Culture”, Med Med J, Vol:33, No:3, pp:227-234, 2018.

 

M. Ozansoy, A. N. Başak, “Tauopathies: A Distinct Class of Neurodegenerative Diseases”, Turkish Journal of Neurology (Turkish), Vol. 13, No: 1, pp: 1-29, 2007. Review

 

M. Ozansoy, A.N. Başak, “Programmed Cell Death in Parkinson’s Disease”, Journal of Parkinson’s Disease and Movement Disorders (Turkish), Vol: 9, No: 1, pp: 54-61, 2006. Review

Oral Presentations

Mehmet Ozansoy, Yağmur Denizhan, A. Nazlı Başak, “Effects of extremely low frequency electromagnetic fields on caspase activities”, pp: 345-351, 1st International Congress on Medical Sciences and Multidisciplinary Approaches, February 20-21, 2021. (Published in full text)

 

Mehmet Ozansoy, Mehmet Özgen Altıntaş, Muzaffer Beyza Ozansoy, “Sodium borate decahydrate affects the fractal dimension of SH-SY5Y cells in an in vitro amyloid-beta toxicity model” pp: 86, International Eurasian Conference on Biotechnology and Biochemistry, December 16-18, 2020.

 

Muzaffer Beyza Ozansoy, Mehmet Ozansoy, “The Effect of N,N-dimethyltryptamine on the fractal dimension of neurite outbranching”, pp:77, 18th Turkish Neuroscience Congress, November 6-9, 2020.

 

Mehmet Ozansoy, Cennet Sena Parlatan, Beyza Çetin Ozansoy, Lütfü Hanoğlu, “Investigation of the effects of two boron containing compounds on neuronal survival in an in vitro axotomy model”, pp:370, 2nd International Eurasian Conference on Biological and Chemical Sciences, June 28-29, 2019.

 

Mehmet Ozansoy, “Effects of extremely low frequency electromagnetic fields on caspase activities”, pp:209, International Eurasian Conference on Science, Engineering and Technology, November 22-23, 2018. 

Mehmet Ozansoy, M. Özgen Altıntaş, Ülkan Kılıç, “Effects of two boron containing compounds and melatonin in Aβ1-42 toxicity”, pp:17; OC-007, 3rd International Congress of Turkish Neuroendocrinology Society, 29th June-1stJuly 2018.

 

Muzaffer Beyza Ozansoy, Mehmet Ozansoy, Nuran Darıyerli, “The Role of Sigma-1 Receptor on Neurite Outgrowth in Primary Hippocampal Neurons” 16th National Neuroscience Congress, pp:98, May 20-23 2018.

Mehmet Ozansoy, Neşe Ayşit Altuncu, Fatma İlayda Aydınlı, Esra Nur Ekmekçioğlu, Gürkan Öztürk, “The Therapeutic Application of Cell Suspension Isolated from Axolotl to Mouse Spinal Cord Injury” 15th National Neuroscience Congress, pp:46, May 07-10 2017.

 

Mehmet Ozansoy, Muzaffer Beyza Çetin Ozansoy, Fikrettin Şahin, Ülkan Kılıç, “The Effect of Melatonin on the Exosome Release and Exosomal Content in In Vitro Amyloid-Beta Toxicity Model” 42nd National Physiology Congress, pp:42, September 05-08 2016.

H.A. Hanağası, M. Ozansoy, H.A. Şahin, B.Bilgiç, İ.H. Gürvit, J.Yazıcı, A. 

Brice, M. Emre, A.N. Başak, “Autosomal Recessive Juvenile Parkinsonism: A

New Parkin Mutation and Clinical Heterogeneity between Family Members”, 

39th National Neurology Congress,  2003

Poster Presentations

Merve Karayel Başar, Emel Akgün, Sebile Arabacı, İrem Kırış, Büşra Gürel, Mehmet Ozansoy, İlknur Keskin, Lütfü Hanoğlu, Nagehan Ersoy Tunalı, Ahmet Tarık Baykal, “Determination of Protein Alterations in YAC128 Transgenic Mouse Brain Tissue with MALDI-MS Imaging Technique”, 24th National Biology Congress, No:PB16, pp:86, September 10-14 2018.

 

B Gürel, AR Mazı, AS Arzuman, C Sevinc, S Kelestemur, B Ocalan, A Cakir, S Aydin, N Kahveci, M Ozansoy, M Cansev, O Taskapilioglu, IH Ulus, B Sahin, AT Baykal, “Investigating Neurological Disease Mechanisms via Proteomics Analysis”, 6th International Congress of Molecular Medicine, pp:36, 22-25 May 2017. 

 

Mehmet Yalçın Günal, Mehmet Ozansoy, Burak Yuluğ, Ülkan Kılıç, Özlem Gök, İlknur Keskin, Muzaffer Beyza Çetin Ozansoy, Ayşe Arzu Şakul, Ertuğrul Kılıç, “The Neuroprotective Effect of Clopidogrel in Experimental Traumatic Brain Injury Model” 42nd National Physiology Congress, pp:102, September 5-8 2016.

Aise Mazi,  Aysegul Arzuman, Mehmet Ozansoy, Ahmet Baykal, “Neonatal Neurodegeneration in 5XFAD Alzheimer’s Disease Transgenic Mouse Model”, 64th ASMS Conference, San Antonio, Texas, USA, June 5-9, 2016.

 

G. Çobanoğlu, M. Ozansoy, A.N. Başak, “Motor Neuron Diseases: Possible Interacting Partners of Alsin and Its Expression”, 47th National Neurology Congress, November 25- December 1, 2011.

 

M. Ozansoy, S. Lahut, G. Çobanoğlu, A.N. Başak, “Possible Interacting Partners of Alsin and Effects of its Expression”, 10th National Congress of Neuroscience, April 9-12, 2011.

 

M. Ozansoy,  Pirkevi C,  Hanağası H,  Emre M,  Ertan S,  Siva A, Lesage S, Brice A, Başak AN, “Molecular Diagnosis of Early Onset Parkinson’s Disease”, 41th National Neurology Congress,2005.

 

M. Ozansoy, Campbell T, Ersoy, N, Craufurd D, Dodge A, Boyaciyan A,

Baral I, Erbes N, Hanagasi H, Kaptanoglu G, Gurvit IH, Emre M, Collinge J,

and Başak AN, “Familial Creutzfeldt-Jacob Disease in Turkey:

Characterization of the Codon 178 Asp-Asn Mutation in a Large Turkish

Kindred” 31st Annual Meeting of the European Society of Human Genetics,

Geneva, Switzerland, 29 May - 1 June, 1999.

 

T Campbell, Ozansoy M, Ersoy N, Yokeş B, Craufurd D, Dodge A, 

Boyaciyan A, Baran I, Erbeş N, Hanağası H, Kaptanoğlu G, Gürvit H, Emre M,

Collinge J, Başak AN.,  “Familial Creutzfeldt-Jakob Disease in Turkey:

Characterization of the codon 178 Asp-Asn mutation in  a large Turkish kindred”, 

34th National Neurology Congress, 1999. 

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